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408(1): 2018/11/14(水)23:03 ID:URcc2/5W(6/8) AAS
The Quest To End Alzheimer’s: Dale Bredesen #522｜By: DAVE ASPREY August 30, 2018
外部ﾘﾝｸ:blog.bulletproof.com
外部ﾘﾝｸ[pdf]:44uc8dkwa8q3f5b66w13vilg-wpengine.netdna-ssl.com
PDF14-15ページより

Dale:　I think the key is gonna be that, although we all agree that many of these approaches are helpful, we were not made to have insulin resistance, so forth and so on.
But you're absolutely right. If we're not careful, we can expose other problems. I'll tell you one we've run into with the treatment of cognitive decline.
We get people on, we drive them into mild ketosis, from 1.5 mm to 4 mm beta-Hydroxybutyrate.
We're getting rid of their insulin resistance, reestablishing insulin sensitivity, addressing their pathogens, addressing detox, all these things.
But what we found is that the people who have BMIs, typically below 20, as they're now decreasing their carbs,
they don't have the adipose tissue to produce the ketones that are supporting their cognition. What happens, they're the ones that actually have problems at the beginning.
省3

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409: 2018/11/14(水)23:04 ID:URcc2/5W(7/8) AAS
（>>408続き）
So as we learn more and more, we can tweak this, and make it better and better. But yes, you're right. These things are not black and white.
You have to, for each person, customize this for his or her genetics, his or her biochemistry. We always talk about genotype and phenotype, but we also want to include the chemotype.
Where do they stand with their biochemistry so that we can address all these appropriately?

Dave: You mentioned cyclical ketosis there, which is something that is a core part of Bulletproof.
I look at people who are on higher carb diets, and they're in a state of relatively high glucose-

Dale: Right, right.

Dave: ... and it never changes. And when you get the idea that, "Okay, that's bad," it's very easy the way humans think, to say, "All right, I want to be in full-blown ketosis all the time, unrelenting, unending."
And that also seems sort of the other side of the coin, of excessive high glucose with excessive high ketones. Whereas we might want to be able to metabolize carbs,
so we go out of ketosis and back into ketosis, and usually have some ketones floating around because of MCTs, or because we fast on a regular basis.
省1

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