[過去ﾛｸﾞ] 【韓国】ネイチャー表紙論文操作されたことと知られて国際恥さらし[12/30] (371ﾚｽ)
上下前次1-新

---

このｽﾚｯﾄﾞは過去ﾛｸﾞ倉庫に格納されています｡
次ｽﾚ検索 歴削→次ｽﾚ 栞削→次ｽﾚ 過去ﾛｸﾞﾒﾆｭｰ

---

126(3): 蚯蚓 ◆MIMIZU/ZLU 2008/12/30(火) 23:06:05 ID:GFNqmiPd(1/2)調 AAS
これですね。

Nature. 2000 Nov 23;408(6811):420-1.
Remission in models of type 1 diabetes by gene therapy using a single-chain insulin analogu
e.
Lee HC, Kim SJ, Kim KS, Shin HC, Yoon JW.
Department of Internal Medicine, Yonsei University, College of Medicine, Seoul, Korea.

A cure for diabetes has long been sought using several different approaches, including islet
transplantation, regeneration of beta cells and insulin gene therapy. However, permanent
remission of type 1 diabetes has not yet been satisfactorily achieved. The development of
type 1 diabetes results from the almost total destruction of insulin-producing pancreatic
beta cells by autoimmune responses specific to beta cells. Standard insulin therapy may not
maintain blood glucose concentrations within the relatively narrow range that occurs in the
presence of normal pancreatic beta cells. We used a recombinant adeno-associated virus
(rAAV) that expresses a single-chain insulin analogue (SIA), which possesses biologically
active insulin activity without enzymatic conversion, under the control of hepatocyte-specific
L-type pyruvate kinase (LPK) promoter, which regulates SIA expression in response to blood
glucose levels. Here we show that SIA produced from the gene construct rAAV-LPK-SIA caused
remission of diabetes in streptozotocin-induced diabetic rats and autoimmune diabetic mice
for a prolonged time without any apparent side effects. This new SIA gene therapy may have
potential therapeutic value for the cure of autoimmune diabetes in humans.
PMID: 11100731 [PubMed - indexed for MEDLINE]
外部ﾘﾝｸ:www.ncbi.nlm.nih.gov

---

上下前次1-新書関写板覧索設栞歴

---

あと 245 ﾚｽあります
ｽﾚ情報 赤ﾚｽ抽出 画像ﾚｽ抽出 歴の未読ｽﾚ

---

ぬこの手 ぬこTOP 0.006s